What are the Side Effects of Depo Provera?

by | Jun 27, 2025 | Defective Drugs, Defective Product, Depo-Provera, Product Liability

Depo-Provera, the brand name for the injectable contraceptive medroxyprogesterone acetate (DMPA), has been widely used for decades by women seeking a convenient, long-lasting form of birth control. While many rely on it for effective pregnancy prevention, serious concerns have emerged regarding the long-term risks and side effects associated with Depo-Provera. The side effects of Depo-Provera include bone density loss, brain tumors, mental health issues, and other life-altering complications. These side effects have prompted public warnings, medical debates, and a growing number of legal actions.

If you or someone you love has suffered adverse effects after receiving Depo-Provera injections, it is important to understand your rights. At Kherkher Garcia, we are committed to helping victims of dangerous or defective medications pursue justice and compensation. In this article, our harmful drug attorneys explore the known risks of Depo-Provera, recent legal developments, and how product liability laws may apply to your case.

Understanding Depo-Provera

Depo-Provera is a hormone-based contraceptive administered via injection every three months. It contains a synthetic form of progestin that prevents ovulation, thickens cervical mucus, and thins the uterine lining to reduce the likelihood of pregnancy. The shot is often prescribed to individuals seeking an alternative to daily birth control pills, or for those who cannot use estrogen-based methods.

Despite its convenience and high effectiveness rate, Depo-Provera has long been the subject of controversy due to a range of serious side effects.

Common and Serious Side Effects of Depo-Provera

Many women report side effects after starting Depo-Provera, ranging from mild to severe. While some are temporary and manageable, others may have long-term health implications.

Common Side Effects:

  • Irregular menstrual bleeding or amenorrhea (absence of periods)
  • Weight gain
  • Headaches
  • Mood swings or depression
  • Acne
  • Decreased libido
  • Hair thinning

Serious and Potentially Long-Term Risks:

  • Bone Density Loss: One of the most alarming side effects is decreased bone mineral density, particularly with long-term use. This condition increases the risk of osteoporosis and bone fractures, especially in younger users who have not yet reached peak bone mass.
  • Brain Tumors: Emerging research suggests that long-term use of Depo-Provera may increase the risk of developing meningiomas, tumors in the brain’s protective lining, which. While typically benign, these tumors can cause serious neurological symptoms like headaches, vision problems, and seizures.
  • Mental Health Effects: Depo-Provera has been linked to increased risk of depression, anxiety, and suicidal thoughts in some patients.
  • Delayed Fertility: While Depo-Provera is marketed as reversible, some users experience delays in returning to fertility—sometimes lasting more than a year after the last injection.
  • Increased Breast Cancer Risk: Some studies have suggested a possible correlation between Depo-Provera use and a slightly increased risk of breast cancer, though findings remain under debate.
  • Immune System Suppression: In rare cases, the shot has been associated with weakened immune responses, increasing vulnerability to infections.

FDA Warnings and Medical Recommendations

In 2004, the FDA issued a black box warning – the agency’s most serious caution – regarding Depo-Provera’s potential to cause significant bone density loss. The warning advises that the drug should not be used for longer than two years unless no other birth control methods are suitable.

Since that time, various medical organizations, including the World Health Organization (WHO) and the American College of Obstetricians and Gynecologists (ACOG), have echoed these concerns, urging healthcare providers to limit long-term use and to monitor bone health in patients.

Despite these warnings, Depo-Provera remains widely prescribed, often without full disclosure of the associated risks.

Legal Developments: Where the Lawsuits Stand

As awareness of Depo-Provera’s risks has grown, so has the number of product liability lawsuits filed against its manufacturer, Pfizer. Plaintiffs allege that the company failed to adequately warn users and doctors about the potential for serious side effects, particularly regarding bone density loss and brain tumor risk.

While many cases have been filed over the past decade, they have largely been handled individually rather than through a consolidated class action or multidistrict litigation (MDL). However, as evidence continues to mount and more women come forward, legal analysts expect the pressure on Pfizer to intensify. Lawsuits relating to Depo-Provera and brain tumors are already being consolidated into MDLs.

Victims seeking compensation typically claim:

  • Failure to warn of known risks
  • Negligent design or testing of the product
  • Medical expenses and ongoing treatment for complications
  • Loss of quality of life or emotional distress
  • Lost wages or earning potential
  • Pain and suffering

How Kherkher Garcia Helps Victims of Dangerous Medications

At Kherkher Garcia, we represent victims who have been harmed by defective or inadequately tested pharmaceutical products. Our experienced legal team understands how drug companies operate, and how often they prioritize profit over patient safety.

If you have experienced serious side effects from Depo-Provera, we can:

  • Investigate your medical history and link your injuries to the drug
  • Review medical literature and warning labels for evidence of negligence
  • Work with medical experts to support your claim
  • Handle all negotiations and legal filings on your behalf
  • Fight for the maximum compensation you deserve

Pharmaceutical litigation can be complex, especially against a powerful company like Pfizer. You shouldn’t face it alone. Our team is here to help you every step of the way.

FAQs About the Side Effects of Depo-Provera and Patient Rights

Q: Can I file a lawsuit if I used Depo-Provera more than two years ago?

A: Possibly. The statute of limitations for product liability varies by state, but it often begins when you discover the injury, not necessarily when you took the drug. If you are just now realizing the link between Depo-Provera and your health issues, contact an attorney immediately.

Q: How do I prove Depo-Provera caused my injury?

A: Through medical records, expert testimony, and documented warnings (or lack thereof), your attorney can help establish a direct connection between the injection and your injury.

Q: Is there a class action lawsuit against Depo-Provera?

A: Currently, most cases are being handled as individual lawsuits. However, this may change as more plaintiffs come forward. An attorney can help determine the best legal strategy for your case.

Q: What types of damages can I recover?

A: Victims may be entitled to compensation for medical bills, lost income, pain and suffering, emotional distress, and long-term care needs.

Q: How much does it cost to hire a lawyer for a Depo-Provera claim?

A: At Kherkher Garcia, we work on a contingency fee basis. You don’t pay unless we win your case.

You Deserve Answers and Accountability

When pharmaceutical companies put profits over safety, real people suffer. The side effects of Depo-Provera are not just inconvenient – they can be physically and emotionally devastating. No one should have to live with permanent injuries because a drug company failed to provide proper warnings.

At Kherkher Garcia, we believe in fighting for those who have been harmed by dangerous medications. If Depo-Provera has impacted your health, you may be entitled to significant compensation. We can help you pursue it.

Call Kherkher Garcia Today for a Free Consultation

If you or a loved one has experienced serious side effects from Depo-Provera, don’t wait. Call Kherkher Garcia now at 713-333-1030 to start your free, confidential consultation. You can also request a consultation and more information by submitting our confidential online contact form.

Let us hold the drug companies accountable while you focus on your health and recovery. We are here to help you seek justice and reclaim your future.

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Steve Kherkher

Steve Kherkher

Founding Partner and Trial Lawyer

This article was written and reviewed by Injury Trial Lawyer and Founding Firm Partner Steve Kherkher. Steve has been a practicing injury lawyer for more than 30 years. He has won $300 Million+ in Settlements and Verdicts for his clients. He is a force to be reckoned with in the courtroom and the trial lawyer you want on your side if you or a loved one have been catastrophically injured.

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